Effect of intermittent and continuous caloric restriction on Sirtuin1 concentration depends on sex and body mass index

Background & aimsThe favorable effect of caloric restriction (CR) on health span is well known and partly mediated by the sirtuin system. Sirtuin1, a regulator energy homeostasis in response to nutrient availability, activated CR. We therefore investigated effects two different CR regimens Sirtuin1 concentrations.Methods resultsThe study included 112 abdominally obese subjects, randomized intermittent or continuous for 1 year. Blood samples anthropometric measures were collected at baseline after 12 months. concentrations measured ELISA. correlated significantly BMI (r = .232, p 0.019). Mean reduction body-weight was 8.0 9.0 kg CR, respectively. After year, no significant between-group differences levels observed according regimen (p 0.98) sex 0.41). An increase median (pg/mL) [25, 75 percentiles] from total population (884 [624, 1285] vs.762 [530, 1135]; 0.041), most marked men (820 [623, 1250] vs. 633 [524, 926]; 0.016). Improvement year changes, but varied sex. In women, Spearman's rho .298, 0.034, with stronger correlation group .424, 0.049). men, there an inverse relation only −.396, 0.045).ConclusionsEffects are BMI-related. Intermittent affected extent than suggesting individualized dietary intervention.